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Letra P


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PARATORMÔNIO - Molécula intacta

Material:

Plasma com EDTA

Instruções de coleta:

Jejum obrigatório, preferência pela manhã. Coletar sangue total, centrifugar e separa o plasma (EDTA) . O PTH intacto é muito lábil à temperatura ambiente, devendo ser congelado entre 2 a 4 horas após a coleta. Condições de armazenamento: 2 horas - temperatura ambiente após coleta 8 horas - refrigerado a 4º C 4 meses - armazenado em frezer a -20ºC 11 meses - armazenado em frezer a -70ºC

Informações:

Diagnóstico diferencial das hipercalcemias, hiperparatireoidismo primário, hiperparatireoidismo secundário, hipoparatireoidismo e pseudohipoparatireoidismo. Habitualmente, a avaliação do PTH é feita em conjunto com a dosagem de cálcio sérico (diagnóstico de hiperparatireoidismo primário), com paratormônio (PTH) elevado e cálcio sérico discretamente elevado. Porém, outras causam de hipercalcemias podem exibir PTH em níveis baixos. No hipoparatireoidismo são encontrados valores diminuídos de cálcio sérico, em conjunto com PTH não detectável ou em concentrações muito baixas. Quando o PTH estiver aumentado, o diagnóstico provável é de pseudohipoparatireoidismo. Nas investigações etiológicas de litíase renal, a dosagem do PTH pode diagnosticar um hiperparatireoidismo. É importante observar que muitos pacientes com insuficiência renal crônica (principalmente pacientes em hemodiálise), podem apresentar elevados níveis de PTH, sem um quadro clínico correspondente. A maioria destes pacientes não tem doença óssea que justifique valores elevados de PTH. É provável que estes pacientes tenham predominância de formas não biológicas ativas, que são medidas pelos ensaios de PTH intacto.

Referência:

  • 15,0 a 65,0 pg/mL
  • Níveis baixos de PTH podem também estar associados
  • a não separação imediata do plasma ou soro, ou ao
  • não congelamento dos mesmos antes da realização
  • Valores de referência alterados em 25/11/2010.
 

Laboratório Bioclinico

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