Manual de Exames

Letra A

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Instruções de coleta:

Coletar em tubo sem anticoagulante, separar o soro e refrigerar.


A neuromielite óptica (NMO), ou Doença de Devic, é uma síndrome inflamatória desmielinizante crônica do sistema nervoso central (SNC). Caracteriza-se por neurite óptica e mielite aguda, que ocorrem de forma simultânea ou seqüencial e seguem um curso monofásico ou recorrente. O diagnóstico diferencial entre a NMO e a esclerose múltipla é muitas vezes difícil nas fases iniciais da síndrome, justamente quando a terapia imunossupressora apresenta melhores resultados. A detecção de anticorpos antiaquaporina 4 contribui muito para essa diferenciação, principalmente nos pacientes em fases precoces, que tiveram um único ataque de mielite longitudinal extensa e que vão evoluir para a NMO clássica. Em tais casos, os outros elementos importantes para o diagnóstico, especialmente os achados de ressonância magnética, costumam estar ausentes.


  • Não Reagente
  • A presença de anticorpos antiaquaporina 4 é
  • consistente com neuromielite óptica e doenças
  • relacionadas. Em pacientes em remissão, a
  • soropositividade indica risco aumentado de recidiv
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